The high-fat diet induces liver damage. atorvastatin has been traditionally used as a Lipid-lowering drug. this work studied the effect of Solanum melongena ethanolic extract on induced liver damage in mice that were treated with a high-fat diet for 14 days by collecting serum biochemical profiles (including GOT, ALP, and GPT), the treated animals showed a decrease in body fat along with necrotic cells in the liver region. S. melongena in high concentrations can lower serum biochemical profiles and hepatic fat formation. Added to this, solanum melongena had no acute oral toxicity in mice. These findings point to the potential of this extract as a hepatoprotective agent against liver damage brought on by a high-fat diet without causing any immediate oral toxicity. Its high total phenolic and flavonoid levels may have contributed, or at least in part, to these actions.