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393267

Therapeutic activity of curcumin in natural and nano forms on copper oxide nanoparticles induced renal toxicity, oxidative stress, and DNA damage in rat

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Last updated: 04 Jan 2025

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Abstract

Metal nanoparticles (NPs) that are considered to be copper oxide nanoparticles (CuONPs) have received more attention in recent years and have a significant impact on everyday life due to their large area of influence. Therefore, the current study sought to explore the therapeutic effects of curcumin (Cur) and/or curcumin nanoparticles (CurNPS) concerning DNA damage, oxidative stress, apoptosis, and inflammation in the kidneys of rats. 60 male rats in the maturity stage were divided into 6 groups (G1, control; G2, Cur; G3, Cur NPS; G4, CuONPs; G5, CuONPs+Cur; G6, CuONPs+CurNPS). Current results revealed a significant elevation in serum levels of creatinine, urea, potassium ions, chloride ions, kidney MDA, DNA damage, kidney injury, PCNA, and P53 expressions, and a significant decline in sodium ions, and calcium ions when compared to control. Interestingly, treatment of CuONPs with Cur or CurNPS revealed modulation in these parameters compared to the CuONPs group with the most favorable results observed in CuONPs+CurNPs.

DOI

10.21608/jbaar.2024.393267

Keywords

copper oxide nanoparticles, curcumin nanoparticles, kidney, Oxidative Stress, PCNA& P53

Authors

First Name

Ehab

Last Name

Tousson

MiddleName

-

Affiliation

Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt

Email

habtousson@science.tanta.edu.eg

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-

Orcid

-

First Name

Mona

Last Name

Dora

MiddleName

A.

Affiliation

Department of Chemistry, Faculty of Science, Menoufia University, Egypt

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-

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-

Orcid

-

First Name

Doha

Last Name

Beltagy

MiddleName

Mohammad

Affiliation

Department of Chemistry, Faculty of Science, Damanhour University, Egypt

Email

-

City

-

Orcid

-

First Name

Hamed

Last Name

Abdel bari

MiddleName

Muhammad

Affiliation

Department of Chemistry, Faculty of Science, Menoufia University, Egypt

Email

-

City

-

Orcid

-

First Name

Azhar

Last Name

Alankooshi

MiddleName

Azher

Affiliation

Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt/ Department of Human Physiology, Faculty of Medicine, Jabir Ibn Hayyan Medical University, Iraq

Email

-

City

-

Orcid

-

First Name

Amira

Last Name

Ahmed

MiddleName

Saber

Affiliation

Hormones Department, Medical Research and Clinical Studies Institute, NationalResearch Centre, Giza, Egypt

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-

City

-

Orcid

-

Volume

10

Article Issue

4

Related Issue

51299

Issue Date

2024-11-01

Receive Date

2024-07-04

Publish Date

2024-11-23

Page Start

866

Page End

878

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 10_Issue 4_Pages 866-878.pdf

PDF . 1.9MB

Link

https://jbaar.journals.ekb.eg/article_393267.html

Detail API

https://jbaar.journals.ekb.eg/service?article_code=393267

Order

393,267

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Therapeutic activity of curcumin in natural and nano forms on copper oxide nanoparticles induced renal toxicity, oxidative stress, and DNA damage in rat

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Type

Article

Created At

25 Dec 2024