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392991

Relationship between Sperm DNA Fragmentation and Interleukin 17 in Patients with Leukocytospermia

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Last updated: 04 Jan 2025

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Abstract

Over the past few decades, fertility treatments have witnessed a remarkable development, inflammation in the sexual glands attached to some patients in addition to immune disorders in patients, which are among the main causes of delayed pregnancy. A hidden molecular cause of infertility is sperm DNA fragmentation which can be attributed to many cases of infertility. This study aims to correlate the relationship between sperm DNA fragmentation and interleukin 17A in patients who suffer from leukocytospermia. Samples were collected from patients with Leukocytospermia (n=30) and healthy individuals (n=18). The present study showed a significant increase in Interleukin 17A levels in Leukocytospermia patients compared with the control group (mean± Std. Error 356.5± 6.14 & 141.37± 1.32) also significant sperm DNA Fragmentation level was noticeably decreased in Leukocytospermia compare with control group (mean± Std. Error 30.85±1.17 & 79.16±3.24 Consecutive). The results show a negative correlation between the Interleukin 17A level and sperm DNA Fragmentation level in Leukocytospermia patients. The study concluded the inflammation of patients affects an increase in the percentage of abnormal sperm chromatin that was assessed using the aniline blue dye. An increase in the level of pro-inflammatory such as interleukin 17 plays a critical role in the pathogenesis and inflammation, while a negative correlation between (Interleukin 17A level and the sperm DNA Fragmentation level in Leukocytospermia patients.

DOI

10.21608/jbaar.2024.392991

Keywords

sperm DNA fragmentation, IL17, leukocytospermia

Authors

First Name

Hayder

Last Name

AL-Msaid

MiddleName

L F

Affiliation

Department of Biology, College of Sciences, University of Kufa, Najaf, Iraq

Email

haiderl.ligan@uokufa.edu.iq

City

-

Orcid

-

First Name

Hydar

Last Name

Khalfa

MiddleName

Muhsin

Affiliation

Department of Biology, College of Sciences, University of Kufa, Najaf, Iraq

Email

-

City

-

Orcid

-

First Name

Ammar

Last Name

Rashid

MiddleName

Adil

Affiliation

Department of Biology, College of Sciences, University of Kufa, Najaf, Iraq

Email

-

City

-

Orcid

-

First Name

Nawras

Last Name

Hussain

MiddleName

Noori Mohammad

Affiliation

Al -mustaqbal University. College of medical and health techniques and science, Department of Medical Laboratory Techniques, Iraq

Email

-

City

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Orcid

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Volume

10

Article Issue

4

Related Issue

51299

Issue Date

2024-11-01

Receive Date

2024-08-20

Publish Date

2024-11-21

Page Start

809

Page End

815

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 10_Issue 4_Pages 809-815.pdf

PDF . 506.1kB

Link

https://jbaar.journals.ekb.eg/article_392991.html

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https://jbaar.journals.ekb.eg/service?article_code=392991

Order

392,991

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Relationship between Sperm DNA Fragmentation and Interleukin 17 in Patients with Leukocytospermia

Details

Type

Article

Created At

25 Dec 2024