"Any chronic or acute problem in the kidneys or heart which can lead to a chronic or acute problem of the other" is known as "cardiorenal syndrome" (CRS). To examine the serum levels of creatinine, urea, IL-1β, NT-pro BNP, albumin, lipid profile, and Troponin levels in the CRS group and compare them to the values in the healthy group. Cardio Renal Syndrome as well as 35 controls were both included in the presented study. All subjects had measured serum levels of creatinine, urea, IL-1β, NT-pro BNP, lipid profile, albumin, and Troponin. This clinical study was completed at private clinics, labs, and the Heart Center in Thi-Qar. Patients diagnosed with CRS had significantly higher mean levels regarding serum triglyceride, LDL, cholesterol, and VLDL, as well as serum creatinine, urea, IL-1β, NT-pro BNP, and Troponin (p ≤ 0.05) in comparison with the control group. The patients had lower serum albumin and HDL than the controls (p ≤ 0.05). ROC curve showed that NT-BNP, Troponin, TCH, IL-1β, LDL, and HDL levels have shown a good approach for differentiating between patients with cardiorenal syndrome and healthy persons. Test results for LDL, TG, urea, VLDL, and creatinine showed a significant ability to distinguish between patients with cardiorenal syndrome and healthy persons. Lastly, the ability of albumin to predict cardiorenal syndrome was found to be low validity. To better comprehend the overall disease burden related to such particular CRS subtypes, an explanation of epidemiology regarding heart-kidney interaction is essential.