Background: Preeclampsia is accompanied by biochemical changes, including hepatic activity, increased blood glucose, thrombocytopenia, urea, creatinine, uric acid, lipid profile changes, hypoalbuminemia, demand for electrolytes, and C-reactive protein. Objective: Our research aims to explore the correlation of one of the well-known biochemical profiles with genotoxicity in preeclampsia COVID-19 patient infection in Mosul, Iraq. Methodology: A cross-sectional study in a cohort of 178 as 58 preeclampsia patients with COVID-19 infection, 60 healthy Pregnant women, and 60 healthy controls attending private clinics were enrolled for this study based on the following inclusion and exclusion criteria. Each of the patients, healthy pregnant, and healthy controls had exfoliated cells from scraping the oral mucosa gathered for micronucleus test, and their whole blood samples were collected to be analyzed for; serum hepcidin, apelin, and galectin-3. Also analyze other biochemical parameters such as iron, ferritin, TIBC, UIBC, transferrin, and TSAT. Results: The results show that the highest MN were in preeclampsia patients with SARS-COV2 at 3.51± 0.471% than in Healthy pregnant as 2.96± 0.109 %. The results revealed that hepcidin and galectin-3 levels of the preeclampsia patients with SARS-COV2 were higher 152.82±14.18 ng\ml, 22.76±3.39ng\ml respectively than healthy pregnant 109.67±10.59 ng\ml, 20.43±3.17ng\ml respectively. Also, the results show that apelin level was lower in preeclampsia patients with SARS-COV2 0.47±0.16 ng\ml than healthy pregnant 0.52±0.14 ng\ml. Conclusion: The preeclampsia patients with Covid-19 infection may have increased in MN and elevated the levels of serum hepcidin, and galectin-3.