This study sheds light on the histopathology structure and histochemistry of the appendix. For a further understanding of the supplement's function. Where (neutrophils) were observed in all the specimens as signs of inflammation. The inflammation extended from the epithelial layer to the muscularis layer.
 Furthermore, it showed cells (neutrophils) Ulcerated in the mucosa, Fat necrosis and Atrophy in payer patches in the submucosa layer, and Hypertrophy in smooth muscle with damage for the same layer, The study included 40 samples, they are suffering from appendicitis, whose weights ranged between 45-75 kg, respectively. The study period was from (1/4/2023 to 7/4/2023). Eosin and hematoxylin, a tissue examination approach, and periodic acid Schiff stains, a histochemistry method, are used in this work, as well as show that PAs staining gave a strong reaction in all layers of the appendix, evidence for the presence of neutral carbohydrates such as neutral mucin and glycogen.