Patient safety is one of the vital disciplines in the medical field, in addition to that, the healthcare workers' safety and protection are also critical, preventing the dissemination and transmission of infectious diseases such as bacterial infections of Staphylococci, Streptococci, Mycobacterium spp, and other viruses such as  Hepatitis B virus, is a critical thing that must be implemented in all healthcare settings, and dental settings specifically, so, achieving many methods to prevent infections and contamination from occurrence and dissemination is so crucial nowadays specifically with the spread of COVID-19 viral infections, several approaches such as Personal Protective Equipment, sterilization, disinfection, and immunization were done to prevent infections and keep patients and healthcare workers, such as dentists, health good. This review discusses the mean infection control approaches from healthcare professionals and dental settings as well as the ways to protect dentists and patients from any infectious diseases in the healthcare dental settings in an effective way.