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332351

Synergistic infection of Helicobacter pylori with IL-Iβ Gene Polymorphism Among the Liver Transplant Recipients

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Last updated: 04 Jan 2025

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Abstract

Background and Objective: Patients receiving liver transplantation are more likely to develop a wide range of infectious complications such as Helicobacter pylori (H. pylori). This study aims to assess the prevalence of H. pylori in individuals receiving liver transplants through the lymph nodes. Moreover, to investigate the relationship between the polymorphisms in the IL-1β gene and the H. pylori infection.
Methods: A total of 43 liver-transplanted patients were selected. They performed a history interview and physical and biochemical examination. The UreA gene and the virulent gene CagA were molecularly screened from paraffin-embedded tissue, additionally, the polymorphism of IL-1β was performed by Polymerase Chain Reaction-Restriction length polymorphism (PCR-RFLP).
Results: all 23(53.5%) patients showed H. pylori infection with UreA gene detection. Out of them 8 (34.8%) were positive for the CagA virulence gene. The infected group with H.pylori showed a significant decrease in albumin (P<0.05). In the case of CagA-positive patients showed a significant decrease in albumin, urine creatinine, HB, platelets, total calcium, and AT III and an increase in urea, creatinine, uric acid, iron, INR, K, TSH, LDH, triglyceride, lipase, and amylase. Analysis of IL-1β (C+3954T), the TT genotype is considered a protective factor, while the CT genotype might be a risk factor for infection. Concerning IL-1β (T-31C) in the case of CagA positive C allele might be protective from infection with CagA-positive strain.
Conclusion: Based on these results, H. pylori appears to have a significant impact on the progression of liver transplanted patients with an interference role of IL-1β polymorphism.

DOI

10.21608/jbaar.2023.245416.1022

Keywords

H.Pylori, Liver transplantation, IL-1β polymorphism, Lymph nodes

Authors

First Name

Asmaa

Last Name

Ibrahim

MiddleName

-

Affiliation

1. Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City (GEBRI, USC), El Sadat city, Egypt. 2. Departments of Medical Parasitology, Faculty of Medicine, Cairo University,

Email

chemistasmaain@gmail.com

City

cairo

Orcid

0000-0001-8119-9549

First Name

Mohamed

Last Name

Nasr

MiddleName

Y

Affiliation

1. Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City (GEBRI, USC), El Sadat city, Egypt. 2. Departments of Medical Parasitology, Faculty of Medicine, Cairo University,

Email

mohamed.younis@gebri.usc.edu.eg

City

cairo

Orcid

-

First Name

Ghada

Last Name

Hassan

MiddleName

-

Affiliation

1. Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City (GEBRI, USC), El Sadat city, Egypt.

Email

ghadahassan3456@yahoo.com

City

cairo

Orcid

-

First Name

Mohamed

Last Name

Saleh

MiddleName

Ahmed

Affiliation

Assistant consultant internal medicine, National Hepatology and Tropical Medicine Research Institute (NHTMRI), Cairo, Egypt.

Email

drasmaaibrahim9011@gmail.com

City

-

Orcid

-

First Name

Ehsan

Last Name

Hassan

MiddleName

-

Affiliation

Pathology Department, National Hepatology and Tropical Medicine Research Institute (NHTMRI), Cairo, Egypt

Email

ehabdelbari@yahoo.com

City

-

Orcid

-

First Name

Khalid

Last Name

Bassiouny

MiddleName

-

Affiliation

Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City (GEBRI, USC), El Sadat city, Egypt.

Email

khalid.bassiouny@gebri.usc.edu.eg

City

cairo

Orcid

-

First Name

Amal

Last Name

Abdel-Aziz

MiddleName

-

Affiliation

Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City (GEBRI, USC), El Sadat city, Egypt.

Email

amal.abdelaziz@gebri.usc.edu.eg

City

cairo

Orcid

-

First Name

Mofida

Last Name

Keshk

MiddleName

A.

Affiliation

Department of Molecular Biology, Genetic Engineering and Biotechnology Research Institute, University of Sadat City (GEBRI, USC), El Sadat city, Egypt.

Email

mofida.keshk@gebri.usc.edu.eg

City

cairo

Orcid

-

Volume

9

Article Issue

4

Related Issue

44938

Issue Date

2023-12-01

Receive Date

2023-10-09

Publish Date

2023-12-01

Page Start

376

Page End

391

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 9_Issue 4_Pages 376-391.pdf

PDF . 1.5MB

Link

https://jbaar.journals.ekb.eg/article_332351.html

Detail API

https://jbaar.journals.ekb.eg/service?article_code=332351

Order

332,351

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Synergistic infection of Helicobacter pylori with IL-Iβ Gene Polymorphism Among the Liver Transplant Recipients

Details

Type

Article

Created At

25 Dec 2024