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331876

Circulating MicroRNA-34a as a Promising Marker for Early Detection of Heart Failure Diseases in Egyptian Patients

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Last updated: 25 Dec 2024

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Abstract

Heart failure has been considered in the last few years as a major factor in global mortality. Heart failure is known as the reduced ability of the heart muscle to fill or/and to pump adequate blood. Finding a diagnostic biomarker is necessary to help in the early diagnosis of heart diseases. MicroRNAs are new biomarkers that have been used for early diagnosis of various diseases. The work aims to study miR-34a in patients with heart failure and assess its diagnosing role. In this work, a total of (120) subjects were divided into three groups as the following, the control group (n=20) of healthy individuals, group II (n=50) the patients with heart failure post myocardial infarction & group III (n=50) the patients with heart failure without myocardial infarction history. microRNA-34a expression showed high expression and significant elevation (P- value < 0.5) in group-II (31.67±11.8 fold) and group-III (27.31±12.4fold) compared with group-I (1.47±0.7 fold). Our results showed that microRNA-34a plays a critical role in patients with heart failure disease and can be used as a biomarker for the diagnosis of early stages of heart failure disease.

DOI

10.21608/jbaar.2023.331876

Keywords

Heart failure, miR-34a, Biomarker

Authors

First Name

Mohamed

Last Name

Nasr

MiddleName

Y.

Affiliation

Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Egypt.

Email

-

City

-

Orcid

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First Name

Ahmed

Last Name

Hassanain

MiddleName

M.

Affiliation

Laboratory Department, National Heart Institute, General Organization for Teaching Hospitals and Institutes, Egypt

Email

a.hassanain1980@gmail.com

City

-

Orcid

-

First Name

Wael

Last Name

El-Hakeem

MiddleName

A.

Affiliation

Critical Care Department, National Heart Institute, General Organization for Teaching Hospitals and Institutes, Egypt.

Email

-

City

-

Orcid

-

First Name

Hamdi

Last Name

Abo Alazm

MiddleName

M.

Affiliation

Environmental Studies and Research Institute, University of Sadat City, Egypt.

Email

-

City

-

Orcid

-

First Name

Randa

Last Name

Ghanoum

MiddleName

A.

Affiliation

Laboratory Department, National Heart Institute, General Organization for Teaching Hospitals and Institutes, Egypt.

Email

-

City

-

Orcid

-

First Name

Sabah

Last Name

El Abed

MiddleName

F.

Affiliation

Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Egypt.

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Ebaid

MiddleName

El-Shahat

Affiliation

Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Egypt.

Email

-

City

-

Orcid

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Volume

9

Article Issue

4

Related Issue

44938

Issue Date

2023-12-01

Receive Date

2023-10-01

Publish Date

2023-12-01

Page Start

311

Page End

321

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 9_Issue 4_Pages 311-321.pdf

PDF . 1.3MB

Link

https://jbaar.journals.ekb.eg/article_331876.html

Detail API

https://jbaar.journals.ekb.eg/service?article_code=331876

Order

331,876

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

Circulating MicroRNA-34a as a Promising Marker for Early Detection of Heart Failure Diseases in Egyptian Patients

Details

Type

Article

Created At

25 Dec 2024