Coronavirus-19 is caused by “Severe acute respiratory syndrome coronavirus-2" (SARS-CoV-2), COVID-19 pandemic, has led to millions of confirmed cases and deaths worldwide. Efficient diagnostic tools are in high demand, as rapid and specific testing plays an important role in patient management and decelerating disease spread. these current technologies used to detect COVID-19 in clinical laboratories will be classified into main three categories, I - The polymerase chain reaction (PCR) method, II - Immunological or serological methods (Antigen and Detection) III - Biochemical and hematological methods which include 1- Inflammatory biomarkers (Elevated and decreased group), 2. Multi-organ damage/failure (Cardiac, Hepatic, and Renal).