Red cell Distribution Width (RDW) and platelet ratio (RPR) are generally accurate predictors of liver fibrosis and cirrhosis in persistent hepatitis B or C. RPR outperformed AST and ALT ratio, AST and RPR index, and FIB-4 as non-invasive techniques to predict liver fibrosis. The aim was to assess the reliability of the diagnosis of liver fibrosis in persistent hepatitis patients with various etiologies using the RDW to RPR with fibroscan. This cross-sectional research enrolled 60 patients with liver cirrhosis brought on by chronic hepatitis C with HCV antibody +ve, chronic hepatitis B with HBs Ag +ve ≥ 6-month bilharzial hepatic cirrhosis and 20 apparently healthy subjects without evidence of any liver disease as controls. Patients and controls were chosen from inpatient and outpatient clinic of Sheben El Kom Fever Hospital and Menoufia Liver Institution. There was a highly statistically substantial positive correlation between FIB 4 and RDW\ Platelet ratio (R = 0.836, P <0.001) and statistically a highly statistically substantial positive correlation between FIB 4 and Liver stiffness (R = 0.337, P 0.009). A reliable test for predicting fibrosis in chronic liver condition was the RDW/ Platelet Ratio. Liver stiffness and RDW/Platelet ratio showed a statistically substantial positive correlation.