To evaluate the vascular response of the macular plexus after pan-retinal photocoagulation using OCT A to prove the hypothesis of its ability to improve macular perfusion in addition to clinically proven regression of neovascularization. A prospective interventional non-randomized study included 15 eyes of 12 patients with proliferative diabetic retinopathy (PDR) or severe non-proliferative (NPDR) with macular thickness < 350 who were candidates for PRP. best corrected visual acuity and expressed in (Log MAR) scoring, central macular thickness and superficial and deep vascular plexus density by OCT A were assessed before and six months following the completion of PRP treatment. The macular vascular density increased after PRP both in the superficial and deep plexus and the change in superficial vascular density only was statistically significant p=0.0034) and also there was a significant increase in central macular thickness (p=0.0023), but no significant change in best-corrected visual acuity (p=0.0961). Improved macular perfusion after PRP more in the superficial capillary plexus, the improvement in vision was not significant as the central macular thickness increased after PRP.