The world traditional medicines used different parts of B. Pilosa in form of juice, decoction, powder, or taken orally have been reportedly used to treat hepatitis, inflammation, hypertension, stomach disorders, and digestive disorders .The aim of this study is to investigate the probable effects of Bidens Pilosa L extract (BP) on complete blood cells and serum antioxidant enzymes level in rats by the dose of (3,6 and 9ml orally/day). Thirty tow male albino rats about (170±10g) were used in this study, and then divided into five equal groups each (8rats). The first one considers a control negative group that fed on a basal diet all the time during the experiment, the other groups (24 rats) was fed on a stander diet + the Oral doses of Bidens Pilosa for (4 weeks). Complete blood cells count levels (HB, HCT, RBCs and PLT) showed significant increases compared with the negativecontrol group. WBCs showed a decrease. For antioxidant enzymes (SOD, CAT, GSH and GPx) were significantly increase comparing with control (-ve). Result of the present study suggests that B. Pilosa may be beneficial for enhancing blood functions and increasing antioxidant enzymes levels.