Effect of Parnof (Pluchea dioscoridis) and Zyzafon (Tilia cordata) water extracts, potassium chloride and salicylic acid, on inhibiting damping-off, root and pod-rot diseases on peanut plants in greenhouse and field was evaluated as seed treatment followed by foliar spraying 35 days after planting. Under greenhouse and field conditions, all treatments reduced target diseases and increased peanut pod yield. Salicylic acid at 5 mM showed the superior effect on all plant parameters in two growing seasons. While, the rest of other treatments alternated between each other in terms of increase and decrease in the efficiency of preventing the diseases under study. Furthermore, in treated plants, all treatments increased accumulation of phenolic compounds and activity levels of oxidative enzymes (catalase, peroxidase, and polyphenoloxidase) compared to untreated plants. Also, new protein bands, may including pathogenesis-related proteins were found in treated peanut plants with electrophoretic analysis. Therefore, our research offers valuable insights into the potential of the inducers, antioxidants, and plant extracts in reducing peanut diseases and presents features that show promise for a strategy of disease control in peanut production.