Objectives: This study was designed to examine the difference among cryolipolysis accompanied with vegan diet against cavitation device accompanied with vegan diet on serum lipid profile in women having central obesity. Methods:  Sixty volunteers' adult females had been involved in this study, aged from 25 to 40 years old. They were given their treatment program from July 2023 to October 2023, a written consent was obtained from each patient. The patients were randomly assigned to one of three equivalent groups; Group A received Cryolipolysis device with vegan diet, Group B received Cavitation device with vegan diet, while Group C received vegan diet only. Body weight, BMI, waist circumference, abdominal skin fold caliper, and serum lipid profiles were monitored for three months during the study.  Results: The results indicated that women in Groups A, B, and C did not differ significantly (P>0.05) in terms of age, weight, height, or body mass index. There were significantly (P<0.05) decreased in weight, BMI, waist circumference, skin fold caliper in abdomen region, and serum lipid profiles after treatment in comparison with before treatment within Group A followed by Group B and then Group C. The women with central obesity in Group B improved body measurement and serum lipid profiles compared to Group A and Group C. No significant differences (P>0.05) in weight, BMI, waist circumference, skin fold calliper in abdominal region, and serum lipid profiles at pre-treatment among Groups A, B, along with C. However, a significant difference (P<0.05) was found in weight, BMI, waist circumference, skin fold calliper in abdominal region, and serum lipid profiles at after treatment among groups A, B, and C. Conclusion: It was concluded that the cavitation technique with vegan diet had the most noticeable decline in measured variables and noticeable improvement in the shape conturing of abdomin followed by cyolipolysis technique with vegan diet then receiving vegan diet only.