Background: Psychological capital is a positive method focuses on the capacity to grow, nurture, improve, and flourish human beings instead of focusing on diseases and disorders. Aim: The objective of the current research was to evaluate the effect of psychological capital program on flourishing and health-promoting lifestyle among patients with depression. Research design: Research^'s aim was achieved through utilizing a quasi-experimental (pre, post, and follow up test) research design. Sample: Sixty depressed patients at Minia Hospital for Mental Health and addiction treatment were selected as a purposeful sample. Tools: Socio-demographic and clinical data sheet, Flourishing Scale, and Health- Promoting Lifestyle Profile questionnaire were utilized. Results:  Findings proved high statistically significant differences in the global scores of Flourishing and Health- Promoting Lifestyle scales before and after program implementation. Conclusion: Psychological capital program is effective in enhancing depressed patients' flourishing and their health- promoting lifestyle profile. Recommendations: More efforts should be undertaken to include psychological capital program as a component of a holistic psychosocial interventions to depressed patients.