Background: The big danger of world health in the 21st century is thought to be climate change, a widespread issue with far-reaching effects especially in vulnerable population as pregnant women. Aim of the study: To assess effect of Climate Change Awareness Program on Knowledge, Attitude and Preventive Practices among pregnant women. Design: Aquasi experimental  research design with one group pre and post-test was adopted in this study. Setting: The study was carried out at antenatal clinics of Women health hospital at Assuit University. Sample: A convenient sample of 100 pregnant women were involved.  Data collection tools: Four tools were used Tool (I) Structured interviewing questionnaire, Tool (II) knowledge assessment tool, Tool (III) pregnant women's attitude toward climate change self-rating scale, Tool (IV) women's reported preventive practices toward climate changes. Results: There is highly statistically significant difference between pre &post-test in relation to pregnant women's knowledge, attitude and preventive practices toward climate changes. Conclusion: The climate change awareness program had a positive effect on enhancing pregnant women's knowledge, attitude and preventive practices regarding climate changes evidenced by pre-test and post-test knowledge, attitude and practice scores. Recommendations: Awareness initiatives are needed for pregnant women to enhance their knowledge, attitude and improve their preventive practices regarding climate change.