Background: The integrative contributions to sustainability development (SD) are purposefully designed to suit the broader vision for maternal health. Hasten sustainable reductions in the maternal mortality besides promotions of maternal empowerment are multidimensional tasks. A devotion to knowledge besides competencies nurses needed to respond to global sustainability challenges for women health. The research aim was to evaluate the effect of educational program on maternity nursing students' perception toward sustainability development: challenges for women empowerment and reducing maternal mortality. Research design; a quasi-experimental research design was utilized to meet the aim of this research. Setting; held at Faculty of Nursing, Tanta University, Egypt. Subjects: A purposive sample of 100 nursing students who at third academic year 2023-2024 from the beforehand stated setting. Three tools were utilized for the data collection; Tool (I): Maternity nursing students' knowledge regarding women empowerment and maternal mortality structured questionnaire; Tool (II): Women Empowerment Attitude Scale (WEAS); besides Tool (III): Sustainability Consciousness Questionnaire (SCQ). Results:  A statistically significant positive improvement of the maternity nursing students' perception was observed at immediately and one month after the implementation of SD program. Conclusion and recommendations: SD program was effective at enhancing maternity students' perception toward SD, women empowerment, and maternal mortality which rendered into higher knowledge, attitude, and behavior scores. Consequently, this program should be conducted endlessly to enhance and refresh nurses' performance in diverse nursing focuses.