Background: Psychosocial rehabilitation of patients with schizophrenia should aim towards empowerment within the framework of individual's mental health promotion. Aim: to identify the effect of psycho-educational training program on empowerment, life orientation & optimism in patients with schizophrenia. Setting: The study was carried out at neuropsychiatric inpatient department of Tanta university hospital. The research design was quasi-experimental. Subjects: 50 patients were chosen as a convenient sample. Tools: Three tools were used: Tool I: Socio-demographic and clinical characteristics Questionnaire, tool II: Empowerment scale (ES), and tool III: life orientation and optimism scale (LOC). Results: This research showed presence of high statistical significance between studied patients' empowerment level, life orientation and optimism immediately and 3 months after implementation of the program than before. Conclusion: This study indicated that the current intervention was effective when it is implemented at rehabilitation stage of treatment of patients with schizophrenia. Recommendations: involving the current program at rehabilitation program for all patients with psychiatric disorders at the hospital.