Background: The frequency and intensity of disasters have increased, making them a serious problem that needs immediate attention. Nurses must possess the ability to offer comprehensive and all-encompassing care to populations impacted by or in danger of disasters to respond appropriately. Aim: The purpose of this study is to investigate the relationship between disaster management factors, challenges, and nurse competencies for disaster risk management among nursing staff. Methods: Utilizing an exploratory descriptive design allowed the current study to accomplish its goal. The study was conducted in the emergency hospital located in the governorate of Menoufia, Egypt, encompassing all in-patient medical, surgical, and intensive care units. There were 154 staff nurses who worked in the operating room, critical care unit, surgical department, burn unit, and emergency department. Results: Staff nurses' responses to disaster risk management factors, challenges, and competencies levels show a significant difference (p<0.0001). Also, a positive association was discovered between elements influencing disaster risk management, challenges, and disaster risk management nurse competence among staff nurses. Conclusion: A highly substantial positive association was discovered between elements influencing disaster risk management, challenges, and disaster risk management nurse competence among staff nurses. Recommendation: For hospital administration to successfully apply disaster management technologies and practices, the organizational culture should be supported and adopted. Ongoing technical training is crucial to creating skilled nurses equipped to handle emergencies.