Background: One of the significant challenge's healthcare faces is ensuring nurses' well-being. Nurses' work-life is based on the concept of involvement between nurses and the overall working environment, when organizations assess the quality of nurses' work-life, organizations will know which areas of work-life need improvement. Aim: To explore the relationship between quality of work life and job involvement among staff nurses. Design: A descriptive correlational study design was utilized. Setting: This study was conducted at Cairo University Hospital. Study Sample: A convenience sample of all available staff nurses (n=193). Tools: Personal data, Quality of Work Life, and job involvement questionnaires were used for data collection.  Results: The findings revealed that 52.3% of staff nurses reported a moderate level of QWL: the highest percent of staff nurses (60.1%) reported a low level of job involvement: the highest mean percentage (61.66 %,) of nurses' responses was related to the work context dimension. Conversely, the lowest percentage (53.75%) of their responses was related to work-life/home life.  Conclusions: There is a strong significant positive correlation between nurses' perception of total and all quality of work-life dimensions: work life/ home, work design, work context, work world, and their job involvement. Recommendations: Hospital administrators and policymakers should establish clear work-life balance policies, develop working standards, and implement strategies that increase staff nurses' workability and healthy lifestyle behaviors affecting their work-life quality. Nurse managers should promote manageable workloads. Nurses should prioritize self-care, hobbies, and activities outside of work to improve their QWL. Further research is required to determine the factors that affect nurses' quality of work life and how they relate to it.