Background: Application of standardized oral care for children receiving artificial respiration can improve the mouth integrity and the overall health status. In addition to preventing infections that may spread to the respiratory tract and consequently shortening the hospital length of stay. The study aimed to determine the effect of a multi - component educational intervention on nurses^, performance regarding oral health care of mechanically ventilated children. Research Design: A quasi experimental design was utilized. Subjects: A convenient sample included 60 nurses from Pediatric Intensive Care Units of Tanta International Educational Hospital and Tanta Main University Hospital. Two tools were used: Nurses^, knowledge assessment questionnaire and oral health care practices observational checklist. Results: Three quarters and all of nurses had low knowledge and unsatisfactory practice pre educational intervention respectively whereas, immediately and one month post the intervention, mothers' knowledge and practice scores have been improved. Conclusion: Educational intervention significantly improved nurses^, performance regarding oral health care of ventilated children. Recommendations: Continuous training for nurses about oral care interventions should be provided. Oral care protocol should be available in every pediatric setting.