Background: Musculoskeletal health is a global concern for school-age children and adolescents. Children often face ergonomic risk factors in their daily activities, so it is important to raise parental awareness to prevent musculoskeletal disorders in their children. Aim: To assess the effectiveness of parent-centered ergonomic educational intervention on their performance regarding safe musculoskeletal growth and development among their school-age and adolescent. Subjects and method: A randomized controlled trial was conducted at pediatric outpatient clinics affiliated with Mansoura University Children's Hospital and Tanta University Hospital. A total of 110 parents and their children were randomly selected. Data collection tool was an interview schedule that included five parts as follow: baseline parents and their children's characteristics; an ergonomics knowledge test, an ergonomics-reported practices checklist, the Standardized Nordic Body Map Questionnaire (SNBMQ), and the Rapid Upper Limb Assessment (RULA). Results: The intervention group of parents showed significant improvements in ergonomic knowledge and reported practices compared to the control group (P < 0.001). Additionally, the children in the intervention group showed significant differences in musculoskeletal pain and posture three months after the education. Conclusion and recommendations: The study suggests that parent-centered ergonomic education can improve knowledge and reported practices and it recommends ergonomic educational interventions to promote safe musculoskeletal growth and development in children.