Background: Ovarian hyperstimulation syndrome (OHSS) stands as the most severe complication arising from fertility treatment. Health information, patients' motivation, and their behavioral skills are critical determinants of healthy behavior and results, according to the Information Motivation Behavior Skill Model (IMB). Aim: The study aimed to evaluate the effect of information motivation behavior skill model on knowledge and self-efficacy of women with ovarian hyperstimulation syndrome. Methods A quasi-experimental study (single group pre/posttest) design was used in this study that was carried out at invitro fertilization (IVF) unit of Ain Shams University Maternity Hospital on a purposive sample of 80 women with ovarian hyper stimulation syndrome. The study utilized a structured interview questionnaire; a women's knowledge assessment questionnaire, and a self-efficacy scale to collect the study's data. Results: The current study shows that 13.7% of the participants demonstrated an adequate level of knowledge before the intervention, which increased to 83.7% at the first follow-up assessment and 73.7% at the second assessment after the intervention, with highly significant differences between them (P < 0.001). Additionally, the total mean score self-efficacy score improved from 37.13 ± 5.83 to 55.14 ± 2.08 at the first follow-up and 54.13 ± 4.07 at the second follow-up assessment, revealing highly significant differences between the two phases (P < 0.001). Conclusion: The current study augmenting that the application of IMB skill model proved to be effective in enhancing the knowledge and self-efficacy of women with ovarian hyper stimulation syndrome. Recommendations: The application of IMB skill model should be integrated as a routine nursing intervention for women with ovarian hyperstimulation syndrome.