Non-alcoholic fatty liver disease is called the silent epidemic mortality for young adults. Lifestyle interventions including healthy diet, physical activity, and exercise programs remain the cornerstone treatment approach for this disease. Aim: To examine the effect of lifestyle interventions on body weight and elevated liver enzymes among patients with non-alcoholic fatty liver disease. Methods: Design: A quasi-experimental design. Subjects: A simple random sample of 200 patients with non-alcoholic fatty liver. Sitting: Outpatients' clinics of Teaching Hospital and the National Liver Institute, Menoufia Governorate, Egypt. Instruments: Five tools: Structured Interview questionnaire, Reported patient's dietary practices questionnaire, The Nordic Physical Activity and Exercise questionnaire-Short, The 24-Hours dietary recall, and Bio-physiological measurements' tool. Results: There were significant post-intervention improvements in the total mean scores among the study group regarding healthy dietary practices as it increased from 37.8±4.6 on pre-intervention to 49.6±5.8 post, body weight measures significantly decreased from 80.0±16.7 pre- to 73.4±18.3 post- and body mass index decreased from 30.1±12.2 pre- to 27.6±13.1 post. Besides, liver enzymes' total post-intervention mean scores for the study group significantly reduced to 43.5±21.9 and 36.9±11.7 compared to the control's 68.2±12.4 and 54.4±12.0, respectively for Aspartate aminotransferase and Alanine aminotransferase, likewise, physical exercise practices' total post-intervention mean scores were statistically significant (p<0.05). Conclusion: Lifestyle interventions; practicing physical exercise and healthy nutrition, proved to be effective in a gradual reduction of both body weight and liver enzymes. Recommendations: Healthy lifestyle modifications should be considered as an initial step for both the prevention and management of Non-alcoholic fatty liver disease.