Background: Domestic health hazards are increasingly seen as a community health problem that could be prevented through increased awareness, proper practices and improvements in the home environment. Aim of the study: This study aimed to evaluate the effect of health awareness program on rural women self- reported practices regarding domestic health hazards. Design: A quasi-experimental research design using pre/ post-test. Setting: This study was conducted at the maternal and child health care center in Sakha village, Kafr Elsheik governorate Subject: A convenient sample of (193) rural women. Tool: A structured interview questionnaire divided into 4 parts. Part (1): Socio-demographic Characteristics, Part (2): Women housing conditions, Part ((3): Women's Knowledge assessment regarding domestic health hazards, part (4): Women's Self-Reported Practices regarding domestic hazards. Results: Reveals that the total good knowledge score level of the studied women regarding domestic health hazards increased from 10.9% in the preprogram to 73.1% in the post program, with a highly statistically significant difference (p < 0.000). There was  a highly statistically significant improvement towards total women's domestic health hazards self-reported practices pre/post-program (25.9%, 88.1%, respectively( at (P≤ 0.001).Conclusion and Recommendation: It could be inferred  that the level of women's knowledge and self- reported  practices regarding domestic health hazards  was significantly improved after  the implementation of the awareness program with a highly statistically significant difference.  The findings of current study indicate that expanding awareness program to include low-income communities for improving their knowledge and practice toward domestic hazards.