Insulin resistance (IR) is more particular to exist in patients with heart failure and is strongly in relation to level of physical activity. Aerobic exercises have been shown to ameliorate the insulin signaling through different molecular mechanisms. Aim: Evaluate the effect of aerobic exercise training on insulin resistance among non-diabetic heart failure patients. Design: A quasi-experimental. Setting: The research was performed at Cardio-thoracic Surgery Hospital at New Minia City which affiliated to main Minia University Hospitals. Subjects: A purposive sample of eighty patients with chronic heart failure were recruited and assigned into either study group or control group (40 patients for each group). Tools of data collection: Patient interview questionnaire and Insulin resistance assessment. Results: The mean scores of waist circumference measurements for the study group decreases significantly from 96.9±11.2, at baseline to, 84.2±6.76 post 12 -week of aerobic exercises training when compared to the control group which is relatively constant. Moreover, there were a statistically significant decrease in the results of the laboratory investigations indices for IR post-12-week of aerobic exercises training in study group as compared to control group. Conclusion: Aerobic exercises have a favorable effect on controlling the prognostic determinants of IR which was obvious in the improvement of anthropometric measurements and laboratory investigations. Recommendations: Conducting training program about aerobic exercise is an essential treatment for IR to improve ongoing surveillance and monitoring relying on preventing the raising of IR and its issues among heart failure patients.