Background: Earlier this decade, the nursing graduates labor market became very competitive with an increasing supply of nursing graduates which put great pressure on nursing graduates to enhance their self-marketing skills and boost their self-esteem. The study aimed to assess intern nurse students' perception of self-marketing skills and its relation to their self-esteem. Design: This study used a descriptive correlational design. Setting: the study was carried out at Cairo University hospitals in different clinical training areas where nursing interns registered for their internship year. Subjects: A convenience sample of 405 intern nurse students who volunteered to participate in this study and registered for the internship year at the Faculty of Nursing - Cairo University were included. Tools: three tools were used for data collection as follows: (a) Personal Data Questionnaire (b) Self-Marketing Skills Questionnaire, and (c) Self-Esteem Questionnaire. Results: the study results demonstrated that the highest percentage (75.10%) of the intern students had a high perception level regarding self-marketing skills. Additionally, about -three-quarters (75.5%) of intern students had a high level of self-esteem. Conclusions: there was a highly significant statistically positive correlation between intern students' total perception of self-marketing skills and their self-esteem. Recommendations: Self-marketing skills should be emphasized in nursing educational programs to enhance graduates' employability.