Background: Female infertility is considered a crisis in women's life and affects different aspects of their quality of life. Infertile women need to improve health-related behaviors and sustain the appropriate quality of life through continuous education. Aim: The study aimed to evaluate the effect of the application of a continuous care model on health-related behaviors and quality of life among infertile women. Design: A quasi-experimental design was utilized. Setting: The study was conducted at the obstetrics and gynecology outpatient clinic and In vitro fertilization ( IVF ) unit at Benha University Hospital. Sampling: A convenient sample of (80) infertile women attended the previously mentioned settings and was divided equally into control and intervention group. Tools: Three tools were used for data collection; a structured interviewing schedule, Health-related behaviors, and a quality of life (QOL) tool. Results: present a highly statistically significant improvement was revealed in the intervention group compared with the control group after implementing the continuous care model (p ≤0.001). Additionally, after the implementation of the continuous care model, the mean ±SD of total quality of life score in the intervention group was higher than the control group, which was (76.13 ± 8.36 versus 56.68 ± 3.92) respectively. Also, there was a highly statistically difference in the total quality of life scores of the intervention group more than the control group (p ≤0.001). Conclusion: Implementing the continuous care model has improved health-related behaviors and the quality of life among infertile women. Recommendations: Integration of the continuous care model as a routine nursing intervention for improving infertile women's health-related behaviors and quality of life.