In today's ever-changing business environment, the Fourth Industrial Revolution is the current and developing milieu in which disruptive technologies and trends such as the Internet of Things (IoT), artificial intelligence (A.I.), robotics, virtual reality (V.R.), and 3D printing are changing the way we live, work, and interact. This paradigm forces companies to become more agile and efficient by automating processes, streamlining operations, and providing better customer service. It will also create new opportunities for businesses to develop innovative products and services. Consequently, these radical changes have proven the essential role of proactive top managers to rescue organizations during risky disasters and to hunt hidden opportunities even in chaotic times. Therefore, this research aimed to define Dynamic Managerial Qualities (DMQ) 's essential role in building a Proactive Manager (PM) in Egyptian business companies in the Fourth Industrial Revolution era. For this, the researcher used the quantitative analysis method and presented several hypotheses tested on a sample of 500 managers in industrial companies in Egypt. Statistically, the researcher received 390 usable responses and used descriptive analysis, correlation analysis, and other statistical tools to confirm the research hypotheses. Accordingly, the researchers concluded that there are two main results. The first is that eight sets of managerial qualities are required for senior Egyptian managers to be proactive in the face of massive change in the dynamic global business environment. Secondly, there is an association between (DMQ) and building a proactive manager in Egyptian commercial firms. Finally, the study suggested an agile transformational model equips senior managers in Egypt with (DMQ) to build a proactive and efficient manager and thus enhance organizational performance.