Early detection of severe acute pancreatitis (AP) is an urgent need to reduce complications and early mortality, and helps in early selection of patients for proper interventions. Aim of study:   to assess the value of TyG index as a severity  predictor of acute pancreatitis. Methods: The study was done on 54 patients who were admitted to hepatology, gastroenterology and Infectious diseases department, Beni-suef University hospital with acute pancreatitis. The collected data of patients within 24 hours of admission were: gender, age, CBC, aspartate aminotransferase, alanine aminotransferase, total bilirubin, albumin, BUN, creatinine, lipase, amylase, CRP, total calcium, ABGs, fasting plasma glucose level, cholesterol, and triglyceride, imaging with abdominal US and chest X-ray. The TyG index and Albumin corrected calcium level were calculated and  were used in evaluated as a risk predictors of acute Pancreatitis. Results: 32 males and 22 females, were divided according to BIS- AP score into two groups: (group 1) 47 patients with mild acute pancreatitis and (group2)7 patients with moderate to severe acute pancreatitis. The TyG index, fasting Blood glucose, BUN, CRP, potassium, white blood cells, calcium and Albumin corrected calcium level showed statically significant differences between two groups. TyG index at cut off (4.94) showed high AUC (0.827), sensitivity (71.4%) and specificity (85.1%), with statically significant differences between . Conclusion: TyG index showed to be promising predictor  of severe acute pancreatitis