Background: A increased risk of morbidity and death is associated with anemia, which is a well-known complication of chronic kidney disease (CKD), particularly in patients with end-stage renal disease who need frequent hemodialysis. Anemia strikes between 49% and 55% of CKD patients, and it becomes more common as the illness progresses. One of the most important signs of iron deficiency in the population-based survey is anemia. Objective: In hemodialysis-dependent patients with chronic renal disease, we evaluated the accuracy of serum soluble transferrin receptors for the diagnosis of iron deficiency anemia. Subjects and methods: we recruited 90 patients of both sexes with end-stage renal disease, ranging in age from 20 to 60 years. A full blood tests, including those for iron, ferritin, total iron binding capacity, saturation with transferrin, and soluble transferrin receptor, were performed on each patient. The data was analyzed using the Pearson correlation and the independent sample t test. It was considered significant when the P value was less than 0.05. Results: The results of our research showed that mean SsTFR level was (55.14±34.2), ranged between 0.3 and 125.9,there was no statistical significant correlation with p-value >0.05 between SsTFR level and all other iron profile tests (hemoglobin, serum iron, TIBC, ferritin, and transferrin Saturation) and there was no a statistical significant higher level SsTFR with p-value 0.05 in cases on dialysis for more than 6 months, and not treated with Erythropoietin and there was  also no statistical significance difference in SsTFR level as regards level of ferritin, or T. saturation.. Conclusion: We conclude that serum soluble transferrin receptors is insignificant in detection of iron deficincy anemia in our CKD patients on hemodialysis.