Background: Hyperemesis Gravidarum (HEG) is the most frequent reason for hospitalization in early pregnancy. The exact etiology is unknown and likely multifactorial. The Helicobacter pylori (H.pylori) infection is linked to peptic ulcers and possibly other gastric disorders. Aim: to determine the prevalence of Helicobacter Pylori infection in pregnant women with hyperemesis gravidarum. Methods: This is a cross-sectional study of 143 women with HEG. They were subjected to clinical assessment and the Pregnancy Unique Quantification of Emesis (PUQE) questionnaire. Routine ultrasonographic and laboratory evaluations were done, and stool testing for H. pyri infection was performed using the IgM ELISA technique. Results: 20 patients (14%) had PUQE scores ≥13, consistent with severe disease. H.pylori was positive in 69 patients (48%), including 75% of those with severe disease (p=0.031). Those with positive H.pylori results had younger ages and were more frequently primigravidae. Conclusion: Helicobacter pylori infection is common in pregnant women with HEG, particularly those with severe disease.