Background: Psoriasis is a complicated inflammatory condition of chronic nature with several etiologies. In addition to an increase in the turnover rate of epidermal cells, psoriasis is characterized by hyperproliferation of keratinocytes in the epidermis. Objective: The objective of the current study was to determine the level of PARP-1 in psoriasis patients compared to healthy controls and its relationship to the severity of the disease. Blood samples from 40 patients with fully developed psoriasis were collected, and each patient's PASI (Psoriasis Areas and Severity Index) score was determined. Patients and methods: Blood samples from 40 healthy volunteers who had no history of psoriasis were also collected, and those blood samples were analyzed using ELISA (enzyme-linked immunosorbent assay). Results: This study provides that the serum level of poly ADP ribose polymerase-1 was significantly higher in patients compared with the controls with no correlation to age, sex or family history (P-value = 0.020). Additionally, the research found no association between the PASI score and the blood level of PARP-1 in psoriatic individuals (r = 0.156, p-value = 0.337). Conclusion: We came to the conclusion that PARP-1 could be involved in the pathogenesis of psoriasis and PARP inhibitors might be an effective adjunct to current anti-psoriatic therapies.