Background: Sharps injury exposure at health-care facilities is regarded as a serious health risk that can result in blood-borne diseases. Worldwide, occupational exposures are frequent, and it's thought that 40–75% of injuries are not recorded. Objectives: This study set out to identify the risk factors for sharp injuries among HCWs working at Beni-Suef University Hospital as well as the prevalence of such injuries during the previous 12 months. Methods: This research was across-sectional analytical study. The study's target population was all of the medical staff at Beni-Suef University Hospital (physicians and nurses from all departments, laboratory and radiology technicians, and waste disposal workers). To collect data, a self-administered structured questionnaire in Arabic was created. The questionnaire was divided into three sections: (participants' sociodemographic characteristics; risk factors for sharps injuries; and frequency of exposure to sharps injuries at the university hospital of Beni-Suef). Results: 54.4% of people had been exposed to a sharps injury in the previous year, according to this survey. Recommendations: It is advised to strictly observe HCWs while they are at work, provide future training to HCWs on safe injection techniques, and continuously check to see if HCWs are adhering to standard precautions and safe injection techniques. Onboarding programs and information sessions must be offered, as well as at suitable intervals.