Obesity represents a global epidemic with serious implications in public health due to its increasing prevalence and its known association with a high morbidity and mortality burden. Obesity is a gateway to ill health, and it has become one of the leading causes of disability and death, affecting not only adults but also children and adolescents worldwide. Diets continue to be the most often used option and some of the most significant clinical therapies for obesity. The present study was designed to find which is more effective in decreasing body weight, whether complete carbohydrate deprivation or decreasing the quantity of food intake to half the content or minimal dose HCG intake.24 Rats were divided randomly into 4 equal groups (Male and Female): Normal control group, Low caloric group, Maximal CHO deprivation group, HCG small dose group. All groups show significant improvement in Body Weight, and serum HDL especially those for low-caloric diets.