Background: The leading causes of mortality and disability globally are coronary artery disease and myocardial infarction, which is its primary consequence. Their growth is significantly influenced by lifestyle choices and the environment. These complicated illnesses also tend to run in families, which points to a significant hereditary component. Clear evidence of a molecular genetic link with coronary artery disease or myocardial infarction has yet to be found, despite significant investigation of several genes. Method: 75 patients were divided into 5 equal groups (control, obese ischemic, overweight ischemic, normal weight ischemic, and Obese noncardiac groups). According to BMI and the results of coronary angiography, patients will be included in one of the study groups mentioned above. Results: Omentin-1 is the highest in the control group and is the lowest in the obese cardiac group. Omentin-1 statistically significant differences existed between the groups. Omentin has; a strong negative correlation with BMI and CRP; a weak negative correlation with Age; a moderate negative correlation with coronary artery disease; no correlation with Lipid profile, Hb A1c, gender, and hypertension. Chemerin is the highest in the obese cardiac group and the lowest in the control group. Chemerin differences between groups were statistically significant, Chemerin has a strong positive correlation with BMI and CRP, a moderate positive correlation with Age and Coronary Artery Disease, a weak positive correlation with HB_A1C, and no correlation with Lipid profile, gender, or hypertension. Omentin-1 & Chemerin have a strong negative correlation between each other. Conclusion: plasma chemerin level was increased, while plasma omentin-1 level was decreased in obese patients with CAD, and they can be considered independent predictors of coronary artery disease in obese patients.