Background: Psoriasis is a complicated inflammatory condition of chronic nature with several etiologies. There is evidence that environmental, genetic, and immunologic factors are involved in its pathogenesis. Toll like receptor (TLR) has been identified among human beings. One of most important toll-like receptors is toll like receptor 2 which is involved in variety of autoimmune disorders. Aim: To determine the role of toll like receptor 2 single nucleotide gene polymorphism in psoriasis patients compared to healthy controls.  Patients and methods: Blood samples from 30 patients with fully developed psoriasis were collected as well as from 30 healthy controls and those blood samples were analyzed using real time PCR. Each patient's PASI (Psoriasis Areas and Severity Index) score was determined. Results: The detection of single nucleotide gene polymorphism was significantly higher in patients compared to controls with no correlation to age, sex or disease severity (P-value < 0.05). Conclusion: Toll like receptor 2 single nucleotide gene polymorphism could be involved in the pathogenesis of psoriasis