Background: Intensive care unit admissions are largely attributed to sepsis in pediatrics. It is essential to diagnose an infection correctly and monitor it closely to optimize treatment and outcomes. Aim: This research was conducted to estimate the diagnostic utility of serum progranulin in pediatric sepsis. Patients and methods: This case-control study included 50 pediatric sepsis patients and 40 healthy matched controls. A peripheral blood sample was taken from the patients and controls then progranulin levels were measured using ELISA. Results: Serum progranulin values were significantly greater in pediatric sepsis patients than in controls (median 180.15 vs.  96.0 ng/ml, respectively: Mann-Whitney p < 0.001). Serum progranulin had good diagnostic power and was the best of laboratory parameters in the diagnosis of pediatric sepsis after CRP with ROC area under the curve (AUC) = 0.998. Using a cutoff value of 116.3 ng/ml PGRN had a sensitivity of 86.0% and a specificity of 100% with a positive predictive value of 100% and a negative predictive value of 85.1%. Serum progranulin levels were positively correlated with body weight and CRP levels and negatively correlated with platelets and hemoglobin levels. Progranulin levels in survivors were not statistically different from those in non-survivors. Conclusions and Recommendations: Serum progranulin may be a good biomarker for sepsis diagnosis in pediatrics.