Background: Viral warts are benign skin growths that are caused by infection with Human Papilloma Virus (HPV). It causes many types of warts according to the type of the infecting virus. It is either genital or non-genital. The disease is infectious and is caused by multiple types of HPV. It usually affects people with low immunity especially those who frequently handle raw meat or use public showers. CXCL 10 is an inflammatory chemokine induced primarily by Gamma interferon (IFN-γ) that plays a major rule in inflammation and binds to CXCR3 to mediate immune responses through the activation and recruitment of leukocytes such as T-cells, eosinophils, monocytes and NK cells. Aim of the Work: The aim of this study is to detect the serum level of CXCL10 chemokine in patient with warts and in healthy control. Subjects and Methods: We performed our study on 2 groups; 45 patients with viral warts and 45 matching relatively healthy controls. We used Enzyme Linked Immunosorbent Assay (ELISA) to measure level of CXCL10 in blood of patients with viral warts and compare it with that of healthy controls. Results: There was a statistically significant difference between the case group and the control group regards serum levels of CXCL-10 in which the mean CXCL-10 of case group was 617.4 (±186.5 SD), while the mean for healthy control group was 549.1 (±157.6 SD) (P-value = 0.036). Conclusion: The study showed that CXCL-10 was differentially expressed in viral warts which suggest that during inflammation IFN-γ increase the gene expression of CXCL10 which plays a role in immune cell invasion to viral infections.