Background and aims: Signs of inflammation and multi organ dysfunction describe a novel clinical disorder called multisystem inflammatory syndrome in children (MIS-C), which is caused by the cytokine storm correlated with SARS-CoV-2. This study aimed to follow up with children with MIS- C correlated with SARS-COV2 infection to determine any sequalae or delayed manifestation of MIS-C. Methods: Children less than 18 years old with a diagnosis of MIS-C were included in this prospective research at the Beni-Suef University Hospital. Comparative analyses of admission and po st discharge clinical and laboratory parameters were performed. Results: Fifty-three children were involved in the research from March 2022 to July 2022 with a mean age of 5.08 ±4.05 years. Fourteen o f the youngsters already had chronic systemic comorbidity. The presence of fever was observed in every case. The hematological (92.45%), GIT, and neurological (56.6%) systems were the most affected. Mo rtality is significantly higher among children with young age, chronic illness, and MIS- C clinical presentation overlapping with COVID-19 infection. Lymphopenia and thrombocytopenia were more common among dead than survivor patients. Conclusions: The prognosis is good for children with no underlying medical conditions. Low lymp hocyte counts and elevated troponin levels may be unfavorable indicators of survival. Positive follow-up results in coronary care were reported.