Aim and background: In this research, we aimed to compare the nasal adhesion prevention after combined endoscopic partial inferior turbinectomy and submucous resection of the nasal septum between 5-fluorouracil and silastic. Patients and methods: 50 individuals with persistent nasal obstruction brought on by hypertrophy of the inferior turbinates and a deviated nasal septum who had not responded to medical therapy were the subject of this investigation. With a mean age of 25, they ranged in age from 16 to 56. 26 patients were men and 24 were women. 25 of these patients were placed in group A (the fluorouracil group), and 25 were placed in group B. (silastic group). Results: Regarding preoperative data, there was no statistically significant difference between the two groups. Conclusion: Our data and statistical analysis revealed that 5-FU application during endoscopic partial inferior turbinectomy combined with submucous resection of the nasal septum is an easy, effective, and safe method in reducing and preventing formation of adhesions as silastic sheet with a significantly lower postoperative pain, headache, and nasal obstruction than silastic in the first week postoperative.