This study was designed to evaluate MAEA gene rs6815464 polymorphism as a risk factor of type 2 diabetes mellitus (T2DM) associated  microangiopathic complications in the Egyptian population. Our patients were divided into two groups; diabetic patients with complications (30) recruited from Diabetes, endocrine and internal medicine clinic, Beni-Suef university hospital, compared with age and sex matched normal volunteers acting as a control group (61). Our study showed that diabetic retinopathy was the most common microangiopathic complication of T2DM (97%) followed by (90%) of the patients had diabetic nephropathy, while (70%) of the patients had diabetic neuropathy. Nonalcoholic fatty liver disease (NAFLD) was significantly higher in diabetic patients than in controls (p < 0.0001*). No significant correlation of MAEA rs6815464 polymorphism with the occurrence of diabetic microangiopathic complications was observed.