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324977

Neutrophil- and platelet-lymphocyte ratios as valuable prognostic biomarkers in ICU COVID-19 patients

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Diagnostic

Abstract

Background: Coronavirus disease 2019 (COVID-19) is a serious pandemic infectious disease that spread all over the world with a wide variety of complications. The need for easily available markers that can assess the severity and prognosis of the disease nowadays is a great demand.  Aim: Study the dynamic changes in NLR and PLR during treatment of confirmed COVID-19 patient in the ICU regarding prognosis and mortality. Method: A retrospective cross-sectional study included 67 patients, with a confirmed COVID-19 by Real time PCR and meet the criteria of hospitalization. Patients were followed up daily for denoting their outcome. NLR and PLR were calculated and compared with other proven biomarkers for COVID-19 to predict prognosis, mortality, and assess their sensitivity and specificity. Result: A total of 67 ICU patients with COVID-19 were enrolled in the current study, 40 were improved and 27 died. Died patients had older age compared with improved patients. Neutrophils were significantly higher among dead patients compared to improved ones (p-value= 0.035). It was found that the NLR & PLR were significantly higher in dead compared to improved patients as follow (p= 0.007) and (p= 0.041), that, may help in the early detection of Covid-19 patients who need more aggressive clinical management. The data showed that there was a high significance of NLR and PLR (p<0.001) in the mortality prediction state. Conclusion: Both NLR and PLR are good predictors biomarkers for severity and mortality in ICU COVID-19 patients.

DOI

10.21608/ejmr.2022.138155.1229

Keywords

COVID-19, Platelet-Lymphocyte Ratio, Neutrophil-Lymphocyte ratio, ICU

Authors

First Name

Maha

Last Name

Mohamed

MiddleName

Fathy

Affiliation

Pulmonary medicine consultant, King Fahd specialist hospital (KFSH). Burayda, Qassim ministry of health, Kingdom of Saudi Arabia. and Assistant professor of chest diseases, Department of Chest Diseases, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.

Email

mahafathy78@gmail.com

City

Beni-Suef

Orcid

-

First Name

Ahmad

Last Name

Aljarallah

MiddleName

Nasser

Affiliation

Pulmonary consultant, Head of pulmonary unit, King Fahd Specialist Hospital (KFSH), Burayda, Qassim ministry of health, Kingdom of Saudi Arabia.

Email

dr_446@hotmail.com

City

-

Orcid

-

First Name

Noha

Last Name

Doudar

MiddleName

A.

Affiliation

Department of clinical and chemical pathology, Beni-Suef University, Beni-Suef, Egypt

Email

noha_ad@hotmail.com

City

Benisuef

Orcid

-

First Name

Hoda

Last Name

Ryad

MiddleName

Ramadan

Affiliation

Department of Biochemistry, Beni-Suef University, Beni-Suef, Egypt.

Email

hoda.abaas@med.bsu.edu.eg

City

-

Orcid

-

First Name

Shaimaa

Last Name

Senosy

MiddleName

A

Affiliation

Department of Public health and community medicine, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.

Email

shoshoahmed80@yahoo.com

City

Beni-Suef

Orcid

-

First Name

Doaa

Last Name

Ahmed

MiddleName

Mabrouk

Affiliation

Department of Medical Microbiology& Immunology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.

Email

doaamicro50@gmail.com

City

-

Orcid

-

First Name

Zahraa

Last Name

Mustafa

MiddleName

Mohammed

Affiliation

Department of Public health and community medicine, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.

Email

zahraa_el_yasmeen@yahoo.com

City

-

Orcid

-

First Name

Asmaa

Last Name

Othman

MiddleName

M

Affiliation

Department of Internal Medicine, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt

Email

assmaa_med@yahoo.com

City

beni_suef

Orcid

-

Volume

4

Article Issue

4

Related Issue

43748

Issue Date

2023-10-01

Receive Date

2022-06-20

Publish Date

2023-10-01

Page Start

78

Page End

93

Print ISSN

2682-4396

Online ISSN

2682-440X

Article File

EJMR_Volume 4_Issue 4_Pages 78-93.pdf

PDF . 715.5kB

Link

https://ejmr.journals.ekb.eg/article_324977.html

Detail API

https://ejmr.journals.ekb.eg/service?article_code=324977

Order

324,977

Type

Original Article

Type Code

1,224

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Research

Publication Link

https://ejmr.journals.ekb.eg/

MainTitle

Neutrophil- and platelet-lymphocyte ratios as valuable prognostic biomarkers in ICU COVID-19 patients

Details

Type

Article

Created At

25 Dec 2024