Background: Much interest was directed towards studying vascular complications in patients with multiple sclerosis (MS). However, the mechanisms of these complications are not well-understood. Objective: our work aimed to evaluate the risk of dyslipidemia in patients with MS and to correlate this risk with disease parameters. Methods: A case-control study included 50 patients with MS diagnosis and 50 age- and sex-matched healthy controls. The incidence of dyslipidemia was assessed in all participants by measuring serum lipid parameters in patients and controls. Results: Serum total cholesterol and triglycerides levels were significantly higher in MS, compared with controls, while HDL-cholesterol levels were significantly lower in MS patients, compared with controls. No significant correlation was found between serum lipids and disease duration or disability. Conclusion: MS patients had significantly higher serum levels of total cholesterol and triglycerides and significantly lower serum level of HDL-cholesterol.