Background: The eye, like any other optical system, suffers from a number of specific optical aberrations. The optical quality of the eye is limited by optical aberrations, diffraction and scatter. Aim of the Work: To compare between the effect of different types of LASIK (proscan ablation and Zyoptix HD ablation) in correction of higher order abberations. Patients and Methods: This comparative prospective study was conducted on 50 eyes of 27 Egyptian patients divided into two groups, Group A: Twenty five eyes of 14 patients (11 patients both eyes and 3 patients one eye) underwent conventional LASIK (Proscan) using mechanical microkeratome. The mechanical microkeratome (Moria) was used to create the flap (superior hinge). The selected plate thickness was 110 µm. And Group B: Twenty five eyes of 13 patients (12 patients both eyes and 1 patient one eye) underwent custom LASIK (Zyoptix HD) using mechanical microkeratome. The mechanical microkeratome (Moria) was used to create the flap (superior hinge).The selected plate thickness was 110 µm. Results: The results found in our study indicate that conventional LASIK surgery was associated with higher values of high order aberrations after surgery than custom LASIK. Compared to the  preoperative status, we found that wavefront guided LASIK (Zyoptix HD) was effective in reduction of HOA than conventional LASIK with no statistically significant difference in HOA 1 week post operative compared to 1 month and 6 months post operative in both custom or conventional LASIK. Conclusion: Zyoptix custom HD treatment is superior to Proscan conventional treatment in the correction of low and high order eye aberrations.