The aim of this study was to investigate the impact of using tylosin antibiotic as growth promoter on growth performance of quail from one day to 42 day of age. Initially, 120 one-day-old quail chicks were fed a basal diet containing 24% protein and 2800 Kcal ME/kg diet for one week. At seven day of age, the chicks were randomly assigned to four groups, each consisting of 30 quail chicks, with three replications of 10 chicks each. The quail chicks were then fed four different levels of antibiotic, namely zero (control), 0.1, 0.2, 0r 0.3 g/kg. The study revealed that feeding birds with diets containing 0.1 g/kg of tylosin led to a significant increase in their average weight gain, while those fed on zero, 0.2, or 0.3 g/kg had the lowest weight gain without significant differences among them. Birds given 0.3 g/kg of tylosin had the best feed conversion ratio (FCR) compared to other treatments. The addition of antibiotic resulted in a reduction in serum total protein and albumin levels in comparison to the control group which had the highest values. Birds that were fed diets containing tylosin also had lower levels of serum cholesterol compared to those without antibiotic supplementation. In conclusion, appropriate use of tylosin antibiotics can enhance the growth performance and economic efficiency of quail in the unique environmental conditions of North Sinai.