ABSTRACT The Corona virus has been a pandemic that grew the attention the medical field from all aspects. Controlling the spread and treating the infected has been the target focus of physiotherapy in ICU. The objectives of this study was to compare the effect of Photobiomodulation using Low level laser therapy to constructed exercise training program on COVID patients in the ICU. Over the course of 7 days 20 patients divided into 2 equal group, group  "A" received treatment through medical interventions and Low Level Laser Therapy (LLLT) without constructed exercise training program and group "B" received medical interventions with Physiotherapy intervening without LLLT. Lab investigations to be compared were recorded on day 1 and day 7 including TLC, CRP, Ferritin, D-dimer, IL-6. The obtained results regarding LLLT group, there were statistically significant differences in ferritin p = 0.005, D-dimer p =0.009, WBCs p = 0.005, and IL-6 p = 0.005. Regarding exercise group, there were statistically significant differences in IL-6 p = 0.005 and CRP p =0.004. Between-groups analysis showed that there was a statistically significant increase in WBCs in the LLLT compared to the exercise group p = 0.002. After seven days, LLLT affected ferritin, D-dimer, WBCs, and IL-6. Constructed exercise training program affected IL-6 p and CRP.