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Phased outbreak of <i>Burkholderia cepacia</i> complex and multi-drug resistant <i>Klebsiella pneumoniae</i> causing neonatal sepsis in a tertiary hospital in Benin City, Nigeria

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Infection prevention and control

Abstract

Background:  Burkholderia cepacia complex (Bcc) is an emerging pathogen known to contaminate pharmaceutical solutions and medical devices, but has largely been underreported as causing infections in Nigeria. This study presents detailed microbiological and environmental surveillance activities of a sequential outbreak of Bcc and extended-spectrum beta-lactamase (ESßL)-producing Klebsiella pneumoniae causing neonatal sepsis in a tertiary hospital in Benin City, Nigeria.  Methods: Blood culture requests were made for neonates upon clinical suspicion of sepsis. Blood specimens were collected in duplicates in BactT/Alert bottles and incubated in the BacT/Alert machine. Further processing of culture-positive bottles was carried out. Identification and antimicrobial susceptibility tests (AST) of emergent organisms were carried out using the VITEK-2 COMPACT system. Environmental surveillance was also done following standard guidelines. Results: During the study period, a total of 303 blood culture requests were received out of which 101 (33.3%) yielded growth of Gram-negative bacilli. Thirty-three (10.9%) yielded Bcc and 41(13.7%) yielded K. pneumoniae (ESßL-producing). All Bcc isolates had similar AST patterns. Various samples from the medical solutions, disinfectants, and environment were negative for the Bcc and K. pneumoniae. However, Bcc and K. pneumoniae (ESßL-producing) were recovered from tap heads and sink drains. Timely infection prevention and control (IPC) interventions led to a decline in the incidence rate. Conclusion: An interplay of proper microbial identification, keen observation, and inter-professional collaboration was key in detailing the phased outbreak of Bcc and K. pneumoniae causing neonatal sepsis. The study highlights the significance of IPC measures in preventing and mitigating the spread of multidrug resistant pathogens.

DOI

10.21608/mid.2024.255175.1713

Keywords

Burkholderia cepacia complex, outbreak, Neonatal sepsis, Klebsiella pneumoniae

Authors

First Name

Ephraim

Last Name

Ibadin

MiddleName

Ehidiamen

Affiliation

Medical Microbiology Division, Medical Laboratory Services, University of Benin Teaching Hospital, Benin City, Nigeria, Infection Prevention and Control Committee, University of Benin Teaching Hospital, Benin City, Nigeria

Email

ibadinsmailbox@yahoo.com

City

Benin

Orcid

0000-0002-8716-4619

First Name

Jeremiah

Last Name

Igunma

MiddleName

Agbons

Affiliation

Infection Prevention and Control Committee, University of Benin Teaching Hospital, Benin City, Nigeria, Medical Microbiology Department, University of Benin Teaching Hospital, Benin City, Nigeria

Email

docigunma@gmail.com

City

Benin

Orcid

-

First Name

Esohe

Last Name

Ogboghodor

MiddleName

Olivia

Affiliation

Department of Public health and Community Medicine, University of Benin Teaching Hospital, Nigeria

Email

olyviadynski@gmail.com

City

Benin

Orcid

0000-0001-6421-6626

First Name

Ikechukwu

Last Name

Okonkwo

MiddleName

R

Affiliation

Department of Child Health, University of Benin Teaching Hospital, Benin City, Nigeria

Email

nananogie@yahoo.com

City

Benin

Orcid

-

First Name

Ewere

Last Name

Ehinze

MiddleName

Scholar

Affiliation

Infection Prevention and Control Committee, University of Benin Teaching Hospital, Benin City, Nigeria, Department of Public health and Community Medicine, University of Benin Teaching Hospital, Nigeria

Email

docescholar@yahoo.com

City

Benin

Orcid

-

First Name

Philomena

Last Name

Irabor

MiddleName

O

Affiliation

Infection Prevention and Control Committee, University of Benin Teaching Hospital, Benin City, Nigeria, Department of Public health and Community Medicine, University of Benin Teaching Hospital, Nigeria

Email

philoirabor@yahoo.com

City

Benin

Orcid

-

First Name

Richard

Last Name

Eriamiatoe

MiddleName

Etinosa

Affiliation

Medical Microbiology Division, Medical Laboratory Services, University of Benin Teaching Hospital, Benin City, Nigeria

Email

richardisetinosa@gmail.com

City

Benin

Orcid

-

First Name

Ebenovbe

Last Name

Idemudia

MiddleName

-

Affiliation

Department of Child Health, University of Benin Teaching Hospital, Benin City, Nigeria

Email

ebenovbeid@gmail.com

City

Benin

Orcid

-

Volume

5

Article Issue

4

Related Issue

51278

Issue Date

2024-11-01

Receive Date

2023-12-14

Publish Date

2024-11-01

Page Start

1,486

Page End

1,493

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 5_Issue 4_Pages 1486-1493.pdf

PDF . 680.7kB

Link

https://mid.journals.ekb.eg/article_338672.html

Detail API

https://mid.journals.ekb.eg/service?article_code=338672

Order

24

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Phased outbreak of <i>Burkholderia cepacia</i> complex and multi-drug resistant <i>Klebsiella pneumoniae</i> causing neonatal sepsis in a tertiary hospital in Benin City, Nigeria: Investigation and mitigation

Details

Type

Article

Created At

25 Dec 2024