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355556

Antimicrobial resistance of multidrug-resistant <i>Enterobacterales</i> and <i>Acinetobacter baumannii</i> isolates to colistin in a Moroccan hospital

Article

Last updated: 25 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Antimicrobial resistance

Abstract

Background:  The challenge of treating infections caused by multidrug-resistant Enterobacterales and Acinetobacter baumannii has significantly increased for medical professionals due to their resistance to conventional antibiotics. In such cases, colistin is employed as a final line of defense. This study was aimed to determine the in-vitro efficacy of colistin against multidrug-resistant gram-negative bacteria. Methods: The research was carried out in the bacteriology department of the Mohammed V Military Teaching Hospital in Rabat, Morocco. 321 isolates of multi-resistant Enterobacterales and Acinetobacter baumannii from various clinical samples were identified by standard microbiological protocols, and the Colistin minimum inhibitory concentrations value was determined using the microdilution method. Results: Of the 321 isolates included in the study, 76.3% were Enterobacterales and 23.6% were Acinetobacter baumannii. The minimum inhibitory analysis showed that 96.3% of the isolates were sensitive, while 3.7% were identified as resistant. The prevalence of resistance to colistin among multi-resistant Enterobacterales was 4.1%, and the MIC50 and MIC90 were 0.5 μg/ml and 1μg/ml respectively. Among the collected Acinetobacter baumannii isolates, the prevalence of colistin resistance was 2.6%, with the MIC50 and MIC90 of 0.5 μg/ml. Conclusion: The research indicates that colistin could be a viable treatment option for infections caused by multi-resistant Enterobacterales and Acinetobacter baumannii.

DOI

10.21608/mid.2024.279217.1862

Keywords

Colistin, Antibiotic resistance, Multidrug-resistant Enterobacterales, Acinetobacter baumannii, Gram-negative bacteria

Authors

First Name

Nadia

Last Name

El mrimar

MiddleName

-

Affiliation

Research Team of Epidemiology and Bacterial Resistance, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat, Morocco, Department of Clinical Bacteriology, Mohammed V Military Teaching Hospital, Rabat, Morocco

Email

drmrimar@gmail.com

City

-

Orcid

-

First Name

El mehdi

Last Name

Belouad

MiddleName

-

Affiliation

Research Team of Epidemiology and Bacterial Resistance, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat, Morocco, Department of Clinical Bacteriology, Mohammed V Military Teaching Hospital, Rabat, Morocco

Email

elmehdi_belouad@um5.ac.ma

City

-

Orcid

0000-0002-6841-7684

First Name

Elmostafa

Last Name

Benaissa

MiddleName

-

Affiliation

Research Team of Epidemiology and Bacterial Resistance, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat, Morocco, Department of Clinical Bacteriology, Mohammed V Military Teaching Hospital, Rabat, Morocco

Email

benaissaelmostafa2@gmail.com

City

-

Orcid

0000-0002-1286-0767

First Name

Adil

Last Name

Maleb

MiddleName

-

Affiliation

Laboratory of Microbiology, Mohammed VI University Hospital, Faculty of Medicine and Pharmacy, University Mohammed the First, Oujda, Morocco

Email

maleb.adil@gmail.com

City

-

Orcid

-

First Name

Mostafa

Last Name

Elouennass

MiddleName

-

Affiliation

Research Team of Epidemiology and Bacterial Resistance, Faculty of Medicine and Pharmacy, Mohammed V University in Rabat, Rabat, Morocco, Department of Clinical Bacteriology, Mohammed V Military Teaching Hospital, Rabat, Morocco

Email

elouennassm@yahoo.fr

City

-

Orcid

-

Volume

5

Article Issue

3

Related Issue

49567

Issue Date

2024-08-01

Receive Date

2024-03-25

Publish Date

2024-08-01

Page Start

1,139

Page End

1,146

Print ISSN

2682-4132

Online ISSN

2682-4140

Article File

MID_Volume 5_Issue 3_Pages 1139-1146.pdf

PDF . 529.0kB

Link

https://mid.journals.ekb.eg/article_355556.html

Detail API

https://mid.journals.ekb.eg/service?article_code=355556

Order

24

Type

Original Article

Type Code

1,157

Publication Type

Journal

Publication Title

Microbes and Infectious Diseases

Publication Link

https://mid.journals.ekb.eg/

MainTitle

Antimicrobial resistance of multidrug-resistant <i>Enterobacterales</i> and <i>Acinetobacter baumannii</i> isolates to colistin in a Moroccan hospital

Details

Type

Article

Created At

25 Dec 2024